预防兽医学系

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郭艳娜

职称:讲师

研究方向:流感病毒的变异、致病性及跨宿主传播的分子机制

所属系列:预防兽医学系

Tel:

Email:gyn13655183568@163.com

学习简历

2019-2023南京农业大学动物医学学院预防兽医学专业,博士

2016-2019南京农业大学动物医学学院预防兽医学专业,硕士

2012-2016山西农业大学动物科技学院动物医学专业,本科

工作简历

2023.9-至今 山西农业大学,动物医学学院,讲师/硕导。

教学科研

主讲本科生《兽医传染病学》和《兽医流行病学》理论与实验以及《兽医传染病学大实验》实践课程,参与研究生《兽医学常用软件课程》授课。

主要从事流感病毒分子遗传进化、病毒变异及跨宿主感染分子机制研究。

代表论文

1.Guo Y, Bai X, Liu Z, Liang B, Zheng Y, Dankar S, Ping J. Exploring the alternative virulence determinants PB2 S155N and PA S49Y/D347G that promote mammalian adaptation of the H9N2 avian influenza virus in mice. Vet Res. 2023 Oct 19;54(1):97. doi: 10.1186/s13567-023-01221-6.

2.Guo Y, Sun T, Bai X, Liang B, Deng L, Zheng Y, Yu M, Li Y, Ping J. Comprehensive analysis of the key amino acid substitutions in the polymerase and NP of avian influenza virus that enhance polymerase activity and affect adaptation to mammalian hosts. Vet Microbiol. 2023 Jul;282:109760. doi: 10.1016/j.vetmic.2023.109760.

3.Guo Y, Ding P, Li Y, Zhang Y, Zheng Y, Yu M, Suzuki Y, Zhang H, Ping J. Genetic and biological properties of H10N3 avian influenza viruses: A potential pandemic candidate? Transbound Emerg Dis. 2022 Sep;69(5):e3171-e3182. doi: 10.1111/tbed.14458.

4.Guo Y, Huang N, Tian M, Fan M, Liu Q, Liu Z, Sun T, Huang J, Xia H, Zhao Y, Ping J. Integrated Analysis of microRNA-mRNA Expression in Mouse Lungs Infected With H7N9 Influenza Virus: A Direct Comparison of Host-Adapting PB2 Mutants. Front Microbiol. 2020 Jul 28;11:1762. doi: 10.3389/fmicb.2020.01762

5.Sun T,Guo Y, Zhao L, Fan M, Huang N, Tian M, Liu Q, Huang J, Liu Z, Zhao Y, Ji Z, Ping J. Evolution of the PB1 gene of human influenza A (H3N2) viruses circulating between 1968 and 2019. Transbound Emerg Dis. 2022 Jul;69(4):1824-1836. doi: 10.1111/tbed.14161.

6.Yu M,Guo Y, Zhao L, Lu Y, Liu Q, Li Y, Deng L, Shi Z, Wang H, Dankar S, Ping J. D2I and F9Y Mutations in the NS1 Protein of Influenza A Virus Affect Viral Replication via Regulating Host Innate Immune Responses. Viruses. 2022 Jun 1;14(6):1206. doi: 10.3390/v14061206.

7.Liu Z,Guo Y, Zhao L, Liu Q, Tian M, Huang N, Fan M, Yu M, Xia H, Ping J. Analysis of the circRNAs expression profile in mouse lung with H7N9 influenza A virus infection. Genomics. 2021 Jan;113(1 Pt 2):716-727. doi: 10.1016/j.ygeno.2020.10.002.

8.Zheng Y,Guo Y, Li Y, Liang B, Sun X, Li S, Xia H, Ping J. The molecular determinants of antigenic drift in a novel avian influenza A (H9N2) variant virus. Virol J. 2022 Feb 5;19(1):26. doi: 10.1186/s12985-022-01755-9

9.Liu Q, Zhao L,Guo Y, Zhao Y, Li Y, Chen N, Lu Y, Yu M, Deng L, Ping J. Antigenic Evolution Characteristics and Immunological Evaluation of H9N2 Avian Influenza Viruses from 1994-2019 in China. Viruses. 2022 Mar 30;14(4):726. doi: 10.3390/v14040726.

10.Huang J, Huang N, Fan M, Zhao L, Luo Y, Ding P, Tian M, Liu Q,Guo Y, Zhao J, Zheng Y, Zhang H, Ping J. Hemagglutinin stalk-based monoclonal antibody elicits broadly reactivity against group 1 influenza A virus. Virol J. 2020 Dec 7;17(1):191. doi: 10.1186/s12985-020-01458-z.

11.郭艳娜,刘志远,孙彤彤等.低致病性A/Anhui/1/2013(H7N9)流感病毒感染小鼠肺组织的miRNA表达谱分析[J].南京农业大学学报,2019,42(03):482-490.